In American English, the word "truck" is often preceded by a word describing the type of vehicle, such as a "fire truck" or "tanker truck". In British English these would be referred to as "fire engine" and "tanker" or "petrol tanker", respectively. In Canada and the United States, "fire engine" is also used.

The United Kingdom and the rest of Europe now have common, yet complex rules (see European driving licence). As an overview, to drive a vehicle weighing more than 7,500 kilograms (16,535 lb) for commercial purposes requires a specialist licence (the type varies depending on the use of the vehicle and number of seats). For licences first acquired after 1997, that weight was reduced to 3,500 kilograms (7,716 lb), not including trailers.

In Australia, a truck driver's license is required for any motor vehicle with a Gross Vehicle Mass (GVM) exceeding 4,500 kilograms (9,921 lb). The motor vehicles classes are further expanded as:

There is also a heavy vehicle transmission condition for a licence class HR, HC or MC test passed in a vehicle fitted with an automatic or synchromesh transmission, a driver’s licence will be restricted to vehicles of that class fitted with a synchromesh or automatic transmission . To have the condition removed, a person needs to pass a practical driving test in a vehicle with non synchromesh transmission constant mesh or crash box.

There are several possible cab configurations:

Cab over engine (COE) or flat nose; where the driver is seated above the front axle and the engine. This design is almost ubiquitous in Europe, where overall truck lengths are strictly regulated, but also widely used in the rest of the world as well. They were common in North America, but lost prominence when permitted length was extended in the early 1980s.

The oldest truck was built in 1896 by Gottlieb Daimler.Most small trucks such as sport utility vehicles SUVs or pickups, and even light medium-duty trucks in North America and Russia will use petrol engines gasoline engines, but many diesel engined models are now being produced. Most heavier trucks use four stroke diesel engine with a turbocharger and aftercooler. Huge off-highway trucks use locomotive-type engines such as a V12 Detroit Diesel two stroke engine. Diesel engines are becoming the engine of choice for trucks ranging from class 3 to 8 GVWs.

North American manufactured highway trucks almost always use an engine built by a third party, such as CAT, Cummins, or Detroit Diesel. The only exceptions to this are Volvo and its subsidiary Mack Trucks, which are available with their own engines. Freightliner Trucks, Sterling Trucks and Western Star, subsidiaries of Daimler AG, are available with Mercedes-Benz and Detroit Diesel engines. Trucks and buses built by Navistar International usually also contain International engines. The Swedish manufacturer Scania claims they stay away from the U.S. market because of this third party tradition.

Common North American setups include 9, 10, 13, 15, and 18 speeds. Automatic and semi-automatic transmissions for heavy trucks are becoming more and more common, due to advances both in transmission and engine power.

A truck frame consists of two parallel boxed (tubular) or C-shaped rails, or beams, held together by crossmembers. These frames are referred to as ladder frames due to their resemblance to a ladder if tipped on end. The rails consist of a tall vertical section two if boxed and two shorter horizontal flanges.

The height of the vertical section provides opposition to vertical flex when weight is applied to the top of the frame beam resistance. Though typically flat the whole length on heavy duty trucks, the rails may sometimes be tapered or arched for clearance around the engine or over the axles. The holes in rails are used either for mounting vehicle components and running wires and hoses, or measuring and adjusting the orientation of the rails at the factory or repair shop.

Though they may be welded, crossmembers are most often attached to frame rails by bolts or rivets. Crossmembers may be boxed or stamped into a c-shape, but are most commonly boxed on modern vehicles, particularly heavy trucks.

There are several aspects of truck operations that contribute to the overall sound that is emitted. Continuous sounds are those from tires rolling on the roadway, and the constant hum of their diesel engines at highway speeds. Less frequent noises, but perhaps more noticeable, are things like the repeated sharp-pitched whistle of a turbocharger on acceleration, or the abrupt blare of an exhaust brake retarder when traversing a downgrade. There has been noise regulation put in place to help control where and when the use of engine braking retarders are allowed.

"Modal shifts account for a nearly a 23% increase in energy consumption over this period. Much of this shift is due to a greater fraction of freight ton-miles being carried via truck and air, as compared to water, rail, and pipelines."According to a 1995 U.S. Government estimate, the energy cost of carrying one ton of freight a distance of one kilometer averages 337 kJ for water, 221 kJ for rail, 2,000 kJ for trucks, and nearly 13,000 kJ for air transport.

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